U.S. regulatory status

NAD+

Also known as Nicotinamide adenine dinucleotide · NAD · β-NAD

In limboNot on the finalized 503A list; no federal ban; compounded in a gray area

Is NAD+ legal right now?

In the United States, NAD+ sits in an unresolved regulatory zone rather than a clearly permitted or clearly banned one. It was nominated for the 503A list, but the advisory committee recommended against inclusion (2017) and the FDA's September 2019 proposed rule listed NAD among substances it proposed not to add; no final rule has definitively placed it on the list. It is not an FDA-approved drug, yet there is no formal federal ban: oral NAD+ is sold as a dietary supplement, and pharmacies continue to prepare NAD+ injections and IV infusions in a gray area. Recent FDA activity has focused on ingredient-quality reminders and product-specific recalls rather than scheduling the substance itself.

In limbo: Nominated or removed from a restricted list but NOT approved - the headline implies a change, but the legal reality did not move.

Verified Jul 7, 2026 (ET) · status held since Sep 5, 2019

Primary source: Federal Register All 3 sources

Where it sits in the process

  1. Nominated
  2. Under review
  3. Rulemaking
  4. Compounding-legal

Not on a path to the 503A list right now. The process stalled or reversed at this stage - read the status above. Sitting at an earlier step is not a sign it will advance.

What changed last

No recorded changes yet - this entry has held one status since it was added.

Status elsewhere

JurisdictionStatusNote
United States (FDA)In limboProposed for non-inclusion (2019); no final rule and no ban; oral sold as a supplement; injectable compounded in a gray area.
Australia (TGA)RestrictedPer a TGA safety alert, NAD/NAD+/NADH are not permitted ingredients in listed medicines.
Sport / anti-doping (WADA)UnscheduledNot named on the Prohibited List, but IV infusions over 100 mL per 12 hours are prohibited as a method (M2).

Sources & transparency

Sources for this entry

Last verified by a human
Jul 7, 2026 (ET) · how we verify
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Peptlas Research Team - independent. About us.
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Confidence
medium - some facts here rest on secondary reporting. Always confirm against the primary source before you rely on it.

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