Reconstitution calculator
Semaglutide reconstitution calculator
A 5 mg Semaglutide vial with 2 ml of bacteriostatic water holds 2,500 mcg per ml - so 500 mcg, as pure arithmetic, is a 20-unit draw on a U-100 insulin syringe. Change any of those numbers and the answer moves; the calculator below does the moving for you, and further down is the thing the vendor calculators never mention: where Semaglutide actually stands with regulators right now.
Semaglutide reconstitution calculator
Math on the numbers you enter - nothing more. Peptlas sells nothing and suggests no amounts.
Concentration
— mcg/ml
Draw volume
— ml
On a U-100 insulin syringe
— units
Draw to — on the 100-unit scale
Enter your intended dose above and the draw appears here, with the math shown.
Results are arithmetic, not advice. Peptlas is a regulatory-status reference: it does not recommend amounts, schedules, or use of any compound. Read the full disclaimer.
What you are working with
Brand semaglutide (Ozempic, Wegovy) comes in pre-mixed dosing pens that need no math. Compounded or gray-market semaglutide is different: a lyophilized powder vial, commonly labeled 2 mg, 5 mg, or 10 mg, that must be reconstituted - which is the only form this calculator concerns.
The reference table below shows the concentration each common vial-and-water combination produces. These are arithmetic facts about Semaglutide vial sizes, not guidance about amounts - the same table exists for BPC-157 and TB-500 (Thymosin Beta-4), with different numbers.
| Vial | + 1 ml water | + 2 ml water |
|---|---|---|
| 2 mg | 2,000 mcg/ml | 1,000 mcg/ml |
| 5 mg | 5,000 mcg/ml | 2,500 mcg/ml |
| 10 mg | 10,000 mcg/ml | 5,000 mcg/ml |
While you are here - where Semaglutide stands
RestrictedSemaglutide is an FDA-approved drug (Ozempic, Wegovy), not a 503A bulk substance. Pharmacies were permitted to compound copies of it only while it sat on the FDA drug-shortage list. After the FDA declared the shortage resolved in February 2025, that permission wound down - ending April 22, 2025 for 503A pharmacies and May 22, 2025 for 503B outsourcing facilities - and the FDA now treats mass compounding of "essentially a copy" of the approved drug as an actionable violation.
The full Semaglutide status page, with every source
What changed last
Public comment period closed on the FDA's proposal to permanently exclude semaglutide from the 503B bulks list (extended from June 30). The proposal is not final - the FDA is now reviewing the record, with no announced decision date.
FDA proposed to permanently exclude semaglutide from the 503B bulks list, finding no clinical need for outsourcing facilities to compound it from bulk. This is a proposal in a comment period, not a final change.
Semaglutide math, asked and answered
- How much bacteriostatic water do you add to a 5 mg Semaglutide vial?
- Any amount - water sets the concentration, not the contents. With 2 ml, a 5 mg vial gives 2,500 mcg/ml; with 1 ml it gives 5,000 mcg/ml. More water means the same dose is a larger, easier-to-read draw on the syringe. There is no single correct volume, which is why this page calculates instead of prescribing.
- How many insulin-syringe units is 500 mcg of Semaglutide?
- It depends entirely on how the vial was reconstituted. As arithmetic: in a 5 mg vial with 2 ml of water (2,500 mcg/ml), 500 mcg is 20 units on a U-100 syringe. With 1 ml of water instead, the same 500 mcg is 10 units. The calculator above does this for your actual numbers.
- Is Semaglutide legal right now?
- Restricted - Semaglutide is an FDA-approved drug (Ozempic, Wegovy), not a 503A bulk substance. Pharmacies were permitted to compound copies of it only while it sat on the FDA drug-shortage list. The full, source-linked answer is on the Semaglutide status page, verified Aug 11, 2026 (ET).
- What form does Semaglutide come in?
- Brand semaglutide (Ozempic, Wegovy) comes in pre-mixed dosing pens that need no math. Compounded or gray-market semaglutide is different: a lyophilized powder vial, commonly labeled 2 mg, 5 mg, or 10 mg, that must be reconstituted - which is the only form this calculator concerns.
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